Massive Feline Kidney Disease Clinical Trial

feline kidney diseaseUsually developing some degree of kidney disease, older cats also can have issues with hyperthyroidism and chronic kidney disease.

Kidneys are made up of thousands of microscopic funnel-shaped tubes called nephrons.

Their job is to filter and reabsorb fluids. Young animals have excessive nephrons available that are held in reserve.

As cats age some nephrons stop functioning and the nephrons in reserve take over and start functioning in their place.

At some point through life, all of the nephrons that can function are functioning.

 Without nephrons left in reserve damage to the kidneys progresses, symptoms of chronic renal disease will start to appear.

Because of the system of reserve nephrons, there are no signs of kidney insufficiency until the damage is really significant.

When many of the nephrons are lost, the kidneys will no longer be able to conserve water, and the animal will pass larger amounts of dilute urine.

By the time that the creatinine levels are elevated and noticed from the  bloodwork, 75 percent of nephrons in both kidneys are gone.

More on Kidney disease from this article from the Wall Street Journal on this  Clinical Trial on the disease.

Thousands Of Cats With Kidney Disease Sought For Groundbreaking Clinical Trial

R ALEIGH, N.C., May 2, 2013 /PRNewswire/ — The largest known veterinary clinical trial of its kind with 35 study sites in the United States and Canada is currently evaluating cats with kidney disease to determine if they also have hypertension (high blood pressure).

Kidney disease and hypertension often occur together, especially in older cats.

Hypertension has been called a “silent killer” and is difficult to diagnose because there are no visible clinical signs in cats.

As in humans, if left untreated, hypertension in cats can lead to serious consequences, including blindness, heart disease, bleeding in the brain, seizures, worsening of kidney disease, and even death.

There are currently no treatments approved by the Food and Drug Administration (FDA) for hypertension associated with kidney disease in cats, so veterinarians must treat this condition with off-label drugs.

This clinical trial, however, is seeking to change that by evaluating a new, easy-to-administer liquid medication for feline hypertension with the goal of gaining FDA approval.

Study seeks to contribute to future improvements in feline health

Read full article here

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